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Nov 30, 1999
Poland: Interim Results of the National Pilot Lung Cancer Screening Program
David MacPherson
USA
David MacPherson
Speaker of: Poland: Interim Results of the National Pilot Lung Cancer Screening Program
Dr. MacPherson is a Professor in the Division of Human Biology at Fred Hutch. His lab is focused on understanding the molecular underpinnings of small cell lung cancer (SCLC). The lab studies SCLC patient samples and employs genetically engineered mouse (GEM) models as well as patient-derived xenograft models to interrogate genes that drive SCLC initiation, progression and response to therapy. Building upon the Rb/p53-deleted mouse model developed by Berns’ group, his lab has generated GEM models with deletions in SCLC tumor suppressors such as Pten, Crebbp and Max and with overexpression of oncogenes such as MYCN. His lab employs GEM and PDX models in therapeutic studies to understand and improve responses to novel and to standard therapies for SCLC.
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