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Nov 30, 1999
Screening in the US Post Nelson
Alvaro Quintanal Villalonga
Speaker of: Screening in the US Post Nelson
Alvaro Quintanal Villalonga is a lung cancer researcher with translational and basic research experience in the field of molecular oncology and targeted therapies, with a special focus on overcoming therapy resistance and combination therapies. During his PhD at the Spanish National Cancer Research Center (CNIO) he studied the role of the tyrosine kinase receptors FGFR (Fibroblast Growth Factor Receptor)1 and FGFR4 in lung cancer. He demonstrated that the pro-oncogenic effects of both FGFRs is conditional and described the molecular contexts in which these are pro-tumoral. On these projects they identified biomarkers of response to FGFR inhibitors (FGFRi) in monotherapy and described the high efficacy of the combination of EGFRis and FGFRis in a subset of non-small cell lung cancer (NSCLC) patients, leading to the initiation of two phase I/II clinical trials with these inhibitors and one patents application. In addition, he led other basic/translational projects related to topics including prognostic/predictive biomarker identification, platinum resistance and novel therapies for lung cancer. In March 2018, Dr. Quintanal Villalonga was recruited by Memorial Sloan Kettering Cancer Center to join Dr. Rudin’s lab, where he focuses his research on the identification of molecular drivers of lineage plasticity in lung cancer leading to histological transdifferentiation from adenocarcinoma to either squamous or small cell carcinoma (SCLC); in the single cell transcriptomic characterization of SCLC; and in the identification of novel therapeutic targets in SCLC, with a focus on chemotherapy resistance.
The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ISLB. The mention of any product, service, organization, activity, or therapy should not be construed as an ISLB endorsement.
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